Free calculator

Semaglutide Half-Life Calculator

Prefilled with the published semaglutide elimination half-life. Enter your dose and the time elapsed to see how much mathematically remains.

This tool does arithmetic on numbers you enter. It does not recommend doses. Talk to your prescriber about your protocol.

Source: Published elimination half-life for semaglutide is approximately 168 hours (about 7 days). Edit the field above if you have a different reference value.

100%0%01234Half-lives elapsed

Remaining amount over elapsed half-lives

Results

Percent of dose remaining
Remaining amount

How it works

  1. Remaining amount = dose amount × 0.5 raised to the power of (time elapsed ÷ half-life)

  2. Every time one full half-life passes, the remaining amount is cut in half

  3. This is arithmetic on the numbers you enter, not a model of absorption or individual metabolism

Worked example

A 1 mg dose with the prefilled 168-hour half-life has about 0.5 mg remaining after 168 hours (one week) and about 0.25 mg remaining after 336 hours (two weeks).

Frequently asked questions

How long does semaglutide stay in your system?

Semaglutide has a published elimination half-life of about 168 hours (about 7 days), prefilled above. Enter your own dose and time elapsed to see the calculated remaining amount for that half-life.

What is a half-life?

A half-life is the time it takes for half of a substance to be eliminated. After one half-life, half the dose remains mathematically; after two half-lives, a quarter remains, and so on.

Does the remaining amount tell me when semaglutide stops working?

No. This calculator only computes a mathematical remaining amount from the dose, half-life, and time you enter. It does not model effect, absorption, or individual metabolism, and it does not recommend a dose or schedule.

Where does the 168-hour figure come from?

It reflects the published elimination half-life for semaglutide. You can edit the half-life field above if you have a different reference value.

Does Peptisy give medical advice?

No. Peptisy performs arithmetic on the numbers you enter. It does not recommend, adjust, or suggest a dose. Talk to your prescriber about your protocol.

Dosing tirzepatide instead? Try the Tirzepatide Half-Life Calculator.

This tool does arithmetic on numbers you enter. It does not recommend doses. Talk to your prescriber about your protocol.